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Bandmann O, Weiss KH, Kaler SG (2015) Wilsons disease and other neurological copper disorders
These enzymes are involved in tagging proteins for degradation via the ubiquitin-proteasome pathway
& Farokhzad, O
Other sources of the SO anion include the short electron chain in the endoplasmic reticulum (ER), cytochrome P450, and the enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which generates substantial quantities --especially during early pregnancy-- and other oxido-reductases [2, 11]
Additionally, iron-activated ERK/MAPK pathways may contribute to tau phosphorylation and neuroinflammatory cytokine release, suggesting a potential feedback loop between iron dysregulation, tau pathology, and inflammation (125, 126)
We opted to investigate S
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